Cytolytic (haemolytic) toxin released by Bacillus cereus. Inactivated by oxygen, reactivated by thiol reduction (hence thiol-activated cytolysin). Binds to cholesterol in the plasma membrane and rearrangement of the toxin-cholesterol complexes in the membrane leads to altered permeability.

Dictionary of molecular biology. 2004.

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  • cholesterol binding toxins — Family of 50 60 kD pore forming toxins from various genera of bacteria including Streptococcus, Listeria, Bacillus and Clostridium. Apparently bind to cholesterol and oligomerise to form a pore: as a result cause cell lysis and are lethal. See… …   Dictionary of molecular biology

  • thiol-activated haemolysins — (= oxygen labile haemolysins) Cytolytic bacterial exotoxins that act by binding to cholesterol in cell membranes and forming ring like complexes that act as pores. SH groups of these toxins must be in the reduced state for the toxin to function.… …   Dictionary of molecular biology

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